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Prokinetic agents such as metoclopramide or domperidone, which accelerate gastric emptying, may counteract some of the therapeutic effects of semaglutide on satiety and weight loss

Compounded semaglutide from licensed 503A pharmacies uses the same active ingredient and meets FDA sterility and quality standards

One practical consideration: the pill must be taken on an empty stomach in the morning with up to 120ml of water, followed by a 30-minute wait before eating, drinking anything else, or taking other oral medications