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Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

This is particularly true for drugs with few reported efficacy data points, making it challenging to accurately estimate their ET50 values

GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)
1 2 "Novo Nordisk's Wegovy bonanza looms large in Denmark"

BMJ 341:c2701 Manfield JH et al (2017) Bariatric surgery or non-surgical weight loss for idiopathic intracranial hypertension
