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For a private prescription, the MHRA licence covers adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related condition

P-values less than 0.05 were considered statistically significant

TM3 (S219 3.22b -A256 3.59b )

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Notably, in healthy human volunteers, acute administration of GLP-1, GLP-1 (9-36amide), or exenatide did not affect blood flow in the mesenteric or renal arteries, excluding splanchnic vasodilatation as a potential mechanism underlying the chronic hypotensive effect of GLP-1 [644]