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10.1016/j.bioadv.2023.213467 [DOI] [PubMed] [Google Scholar] Turner J
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Mice with PVN-selective deletion of GLP-1R (using Sim1 cre) have impaired stress-induced HPA axis activation, and this is further accompanied by protection from stress-induced weight loss, reduced stress-induced cardiovascular endpoints and reduced anxiety-like behavior [813]

Second, the reduction in fat mass, particularly visceral fat, removes a major source of inflammatory cytokine production