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The landmark LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) trial, which enrolled 9340 individuals with T2D at high CV risk, demonstrated that liraglutide significantly reduced the incidence of major adverse cardiovascular events (MACE) compared with placebo over a median follow-up of 3.8 years (Hazard Ratio [HR]: 0.87

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You take it about an hour before eating

The ongoing FOCUS trial investigates the long-term effects of semaglutide compared with placebo on diabetic retinopathy, including relatively well-regulated (HbA1c 710%) patients with T2D (51)