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The early initiation of Metreleptin, a recombinant analog of human leptin, in generalized lipodystrophy patients is essential to delaying or preventing metabolic complications, lowering HbA1c, triglycerides, proteinuria, and improving liver health [105]

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NLM (2021): STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

The most common side effect described, with respect to the total number of related topics, groups, and discussions, was nausea, followed by vomiting, constipation, injection site issues, pancreatitis, and gastroparesis

Patients should consult their healthcare provider to discuss the risks and benefits.