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The SUSTAIN-6 trial, which tracked over 3,000 patients using semaglutide for diabetes management, reported depression or depressed mood in less than 2% of participants taking the medication versus similar rates in the placebo group

Cardiovascular side effects with semaglutide are generally mild, and the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in people with established heart disease

The body needs time to become metabolically flexible, efficiently switching between glucose and fat oxidation

Each episode of vomiting or diarrhea strips nutrients from your body before they can be absorbed

But experts warn that using Ozempic without a prescription, or for reasons other than diabetes management, comes with risks