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In the CNS, endogenous GLP-1 acts primarily through vagal afferent signaling, transmitting information from the gastrointestinal tract to the brainstem [123, 124]
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According to NICE guidance, the target HbA1c for most adults with type 2 diabetes is 48 mmol/mol (6.5%), though individualised targets may be higher based on factors such as age, duration of diabetes, and risk of hypoglycaemia
Several studies demonstrated that inactivation of TLR5 determines dysbiosis characterized by altered abundances of more that 100 phylotypes and a bloom in Enterobacteriaceae, especially E
