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GLP-1R trafficking is relevant in vivo We next investigated the therapeutic potential of exendin-phe1 in mice fed with a high fat and high sucrose (HFHS) diet, an animal model of T2D

That philosophy lines up with current guidelines, which support personalized dosing tailored to each person's goals, health benefits, and tolerance

When patients report a dramatic reduction in opioid cravings from a drug that was prescribed for a different condition (diabetes or obesity), it is unlikely to be a placebo effect because the reduction in cravings was not the goal or an expected impact of the treatment

2024, doi: 10.1016/j.annemergmed.2024.03.007
