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GLP-1 is secreted as a pro-peptide that is then proteolytically cleaved into two active forms, (7-37) and (7-36)
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Mice were then given daily subcutaneous (SQ) injections of semaglutide (12 g/kg) for 14 days and changes in bodyweight and food intake were recorded (Fig
Clinical Pharmacology and Therapeutics 2013 93:2 (186-194) DOC ID 0900babe80a77c2d
The MHRA has issued safety communications on this issue
