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While the effects of GIPR agonism may be confounded by other anti-inflammatory variables such as weight loss and improvements in glucose homeostasis, GIP unquestionably has an important, albeit enigmatic, role in immune signaling

Abstract Glucagon-like peptide-1 receptor agonists are a class of drugs that mimic a natural incretin hormone released by the intestine after meals, and they are well-suited for treating type 2 diabetes

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This has led to the development of semaglutide, currently considered as state-of-the-art for GLP-1 RAs

Lack of brain penetrance in this context meant that the compound was not even detected in the area postrema