semaglutide structure File:Semaglutide PDB=7ki0.png - Wikimedia Commons

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The alanine at position 8, the residue immediately adjacent to the DPP-4 cleavage bond, is replaced by alpha-aminoisobutyric acid (Aib), a non-canonical, doubly methylated amino acid whose steric bulk blocks protease access [1]

Following an overnight fast, mice received an oral gavage of glucose at a dose of 2 mg per gram of body weight

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