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[(accessed on 12 March 2024)];JAMA

These included ad libitum energy intake, ratings of appetite, thirst, nausea, well-being, control of eating, food preference, resting metabolic rate, body weight, and body composition

Schwartz Hypothalamic and hindbrain neurocircuits that regulate food intake and energy expenditure in response to input from the adipocyte hormone leptin.

These inconsistencies pose challenges in comparing studies, establishing definitive doseresponse relationships, and extrapolating results from rigorously characterized preparations used in clinical trials to the heterogeneous products accessible to consumers (569)

In the previous paragraphs we have reviewed evidence for the clear suppression of food intake by mesolimbic GLP-1 activation