what is a known effect of glp-1 Should I take like Ozempic or Wegovy? — Those Nerdy Girls GLP-1 actions in peripheral tissues.

If you pause your medication for more than a few weeks, your body may re-sensitize to semaglutide, meaning some patients experience stronger appetite-suppression effects when they resume

[DOI] [PMC free article] [PubMed] [Google Scholar] [126].Tabassi A, Salmasi AH, Jalali M (2005)

While a negative feedback loop has not been identified, the very high levels of these medications not only flood the body, but do so for extended periods, unlike endogenous GLP-1, which normally fluctuates in response to eating

oxidative stress, calcium overload, and glutamate toxicity may also lead to energy deficiencies, forming a vicious cycle with -synuclein accumulation

Lancet Public Health 2 , e277e285 (2017)