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Description
These reports include cases of dosing errors, contamination, and unexpected side effects that may result from inconsistent manufacturing processes

Monitoring and follow-up: Regular follow-up during the first 3-6 months of therapy allows for symptom assessment, dose optimization, and early identification of complications

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These cytokines also contribute to IR through mechanisms including inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, while also promoting glucocorticoid resistance and HPA axis hyperactivity [80]

Biology adapts, and side effects often appear during titration windows, so a static calendar is fragile
