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This model is also satisfying from an evolutionary biology perspective in which GLP-1 and GIP do not have redundant functions in the brain, but rather fit into complimentary niches

At home or at the doctor

Side effects are possible with any medication

Increase your daily water intake to at least 2.53 liters per day, and drink fluids before, during, and after physical activity

In practice, this means tirzepatide often produces slightly less nausea at equivalent dose escalation points (thanks to the GIP component), potentially stronger appetite suppression once doses reach therapeutic levels, and additional metabolic benefits that semaglutide does not provide