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The Achieve-3 trial, funded by Eli Lilly, studied more than 1,500 adults with type 2 diabetes from 131 medical research centres and hospitals in Argentina, China, Japan, Mexico and the US

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Studies have reported that excessive intake of histidine can cause hepatic steatosis ( The pro-inflammatory cytokines (IL-6 and TNF-) released during the pathophysiology of NAFLD are mainly derived from macrophages ( Arachidonic acid, a polyunsaturated fatty acid metabolized by cyclooxygenase and lipoxygenase pathways, can mediate inflammation and participate in the development of NAFLD
