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Nearly every SLE patient takes it, and guidelines recommend it be continued indefinitely
Specifically, the composite kidney outcome had a risk ratio of 0.79 (95%CI: 0.66-0.95), and the eGFR slope showed a reduction of 0.78 mL/minute/1.73 m 2 /year (95%CI: 0.57-0.98), with no significant heterogeneity observed ( P -heterogeneity = 0.53 and 0.94, respectively)
The mechanism is that GLP-1 exerts its glucagon inhibitory effect in human pancreatic islets through an intrinsic (non-paracrine) PKA-dependent effect mediated by the activation of the few GLP-1Rs present in the plasma membrane of -cells, which ultimately inhibits P/Q-type Ca2+ channels (Ramracheya et al., 2018)
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GLP-1 also inhibits gastric emptying [7], which contributes to reducing postprandial glucose excursions
