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Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)

In obesity, Novos Wegovy (semaglutide injection) was approved in 2021, however uptake has been hindered by access limitations, with no Medicare coverage and limited coverage among commercial plans

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Moreover, the OXMQ3E peptide was unable to produce any weight loss in Glp1r -/- mice, suggesting that both GLP-1R and GCGR are required for weight loss to occur