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The dual-receptor modifications that make tirzepatide so effective as an injectable, the GIP receptor binding, the C20 fatty acid chain, the Aib substitutions, also make it more structurally complex and harder to protect during oral transit

A., Gunday S., Iqbal A., Alrushaid N., et al

And in a recent survey of state Medicaid directors conducted by KFF, a health policy research organization, they said cost and potential side effects are among their concerns

Gastaldelli A, Cusi K, Fernndez Land L, Bray R, Brouwers B, Rodrguez (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial