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Prescription GLP-1 receptor agonists have undergone rigorous, large-scale clinical trials showing significant efficacy in lowering blood glucose levels, promoting substantial weight loss, and even offering cardiovascular benefits in some cases

FDA Commissioner Marty Makary stated: "When FDA-approved drugs are available, outsourcing facilities cannot lawfully compound using bulk drug substances unless there is a clear clinical need." If the proposal is finalized, it closes the primary remaining pathway for large-scale compounded GLP-1 production in the United States

Recent studies have demonstrated that the GLP-1 agonist, liraglutide, exerts an antipsychotic effect in a mouse model of psychosis (Lietzau et al., 2020)

A study released last year by the National Institutes of Health found that once patients go off medications for weight loss, the average weight gain rebound is about two-thirds of the total weight loss

Some researchers believe that improving this connection with GLP-1 receptor agonists could have indirect benefits for mood regulation