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[92] and was confirmed by others [667,698]

The gastrointestinal side effects, whilst common, were manageable and typically resolved with continued treatment or dose adjustment

A recent study investigated the effects of GLP-1R agonists in a multi-hit mouse model in which the combination of a high-fat diet and angiotensin II-induced a cardiometabolic HFpEF phenotype that resembles the human HFpEF phenotype to a large extent characterized by obesity, impaired glucose handling, and metabolic dysregulation accompanied by inflammation

For researchers, this necessitates a careful consideration of safety protocols, especially regarding heart rate