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Polycystic ovary syndrome affects approximately one in ten women of childbearing age, and up to 70% of those with PCOS experience insulin resistance

Notably, caloric restriction (CR) and moderate weight loss (approximately 510%) improve insulin sensitivity despite the accompanying loss of muscle mass, and the observed reduction appears to result primarily from increased proteolysis rather than reduced protein synthesis

Background Scientists have studied Alzheimers disease for over a century, since Alois Alzheimers initial description of brain abnormalities in a patient with presenile dementia

GL, generalized lipodystrophy

doi: 10.1037/hea0000207 61 ForsytheP.SudoN.DinanT.TaylorV