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Thus, GIP is a likely candidate for mediating some of the therapeutic actions of DPP-4 inhibition, and the recent development of a GIP receptor antagonist suitable for use in clinical studies (50) should allow this hypothesis to be tested
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These combined actions of GLP-1R signaling cause improvements in glycemic control as well as weight loss in type II diabetes (T2DM) patients treated with GLP-1R agonists
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