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Maintaining results long-term The hard truth about GLP-1 medications is that many patients regain weight after discontinuation

If you feel the medication has completely stopped working (e.g., appetite returned to baseline, no appetite suppression), discuss with your provider

This is the window where your timing choice matters most

Retatrutide is the only compound that attacks the energy balance equation from both sides: reducing appetite through GLP-1 and GIP activity, while simultaneously increasing energy expenditure and fat oxidation through glucagon receptor activation

The good news is that this fatigue typically improves significantly by week 8 as your body adjusts to the medication