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This dual action potentially makes Tirzepatide more effective in promoting weight loss and improving metabolic health compared to medications that target only GLP-1 receptors

10.1016/j.cmet.2010.04.007 28 de VosW

Importantly, these medications carry a boxed warning about thyroid C-cell tumors observed in rodent studies and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

While they may not be as effective as GLP-1s, they can still support weight management efforts

106 It has been discovered that providing Liraglutide to AD patients for 6 months increases the ability to transfer blood-brain glucose, allowing the reestablishment of glucose transport, a vital initial step in improving brain alterations
