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For persistent symptoms, intra-articular corticosteroid injections or duloxetine may be appropriate adjunctive therapies

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Semaglutide has an extended half-life of 160 h and offers a significant advantage since it is also available as a daily oral formulation

Because tirzepatide targets both GLP-1 and GIP receptors, researchers are evaluating whether dual agonist therapies may produce even greater functional improvement in obesity-related osteoarthritis