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The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke
Semaglutide was removed in February 2025

however, this contradicts established trial data favoring SGLT2 inhibitors for heart failure and should be interpreted cautiously due to possible residual confounding

Survodutide also reduced waist circumference, an indicator of metabolic health.
Is allulose a natural alternative to GLP-1 drugs for fat loss
