her glp-1 Drugs and the Physiology of Metabolic Health Brain scientists are seeking weight-loss
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These effects typically occur during dose initiation or escalation and often diminish over time as the body adjusts to the medication

Time to peak concentration for the oral agent is 1 hour and I suppose the trial was designed to have the concentrations at their highest when a patient begins to eat
J Alzheimers Dis (2010) 19(4):120519

If successful, this would be a life-changing advance
Some patients respond extremely well to semaglutide, while others experience stronger appetite control with tirzepatide