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This region includes the nucleus tractus solitarius and the area postrema, which together receive and integrate signals from the gut and the bloodstream
The SELECT trial documented significant CRP reductions that correlated with but were not entirely explained by weight loss

Individuals often blame weight gain and poor health on carbohydrates in their diet because of nutrition misinformation online

diabetes investigation 2 (3), 210217

The resultant bacterial overgrowth produces succinic acid, which enhances the virulence of enteropathogenic Escherichia coli (e.g., promoting Tir and Ler gene expression) and increases epithelial invasiveness