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Once-daily GLP-1 receptor agonist therapies are also available in fixed-ratio combination formulations with long-acting insulins (insulin glargine with lixisenatide [22] and insulin degludec with liraglutide [23])

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While the exact mechanisms underlying these gastrointestinal disturbances remain incompletely elucidated, they are believed to stem from the actions of GLP-1 RAs on gastrointestinal motility and secretion [6]

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