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By producing sustained weight reduction and favorable changes in lipids, blood pressure, systemic inflammation, and endothelial biology, tirzepatide targets the central pathophysiological drivers of obesity-related HFpEF

Ozempic and Rybelsus are approved for type 2 diabetes, while Wegovy is approved for chronic weight management and cardiovascular risk reduction

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Both medications should be used alongside diet and exercise as part of a comprehensive treatment plan guided by a healthcare provider

Evidence and rationale The data supporting this recommendation are derived from the management of nonsurgical patients taking GLP-1 RAs who have severe symptoms related to the drugs