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In the active-controlled trials, semaglutide 14 mg demonstrated greater reductions in body weight compared to sitagliptin and liraglutide at 26 weeks, with the exception empagliflozin in PIONEER 2 where no statistically significant difference was observed

However, the absolute risk remained low , and the study's observational design could not definitively establish causation

Effectiveness depends on individual health needs and how each person responds to the medication

Individual results may vary, but studies have shown significant weight loss with Semaglutide treatment for several months