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Liver and kidney function: Routine labs showed no consistent dose-dependent hepatotoxicity or renal impairment in Phase 2 Clinical Monitoring Protocols Participants in trials underwent ongoing monitoring to ensure safety during dose escalation: Liver enzymes (ALT, AST) for hepatic stress Renal function tests to watch for dehydration-related strain from GI side effects Cardiovascular markers such as blood pressure, heart rate, and lipid levels Blood glucose and HbA1c in diabetic and non-diabetic populations Discontinuation Rates Despite concerns about higher-dose tolerability, discontinuation due to adverse events was comparable to other GLP-1 and GIP receptor agonists

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However, the overall process remains strict and selective

He explains how pediatric bipolar can present differently from adults, why family-centered care and psychoeducation matter, and how meds remain first-line while diet may help reduce relapse and symptom burden

Result: Shedding peaked around month 5-6, then gradually decreased