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Someone with a high-risk variant in this gene may experience stronger hunger signals naturally, making standard-dose semaglutide insufficient without additional therapeutic support
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Muni, MD MSc FRCSC, associate professor and vice chair of Clinical Research in the Department of Ophthalmology and Vision Sciences at the University of Toronto in Canada, and principal investigator of this study explained to Medical News Today

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the slides were stained with diaminobenzidine (DAB) (mouse and rabbit HRP/DAB (ABC) detection IHC kit, ab64264, Abcam, UK), as illustrated in the datasheet, and the immunoreactivity was visualized as a brown color