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For example, in the STEP UP Diabetes trial, participants taking 7.2 mg of semaglutide weekly lost an average of 13.2% of their initial weight, compared to 10.4% for those on the standard 2.4 mg weekly dose

Blood Glucose Homeostasis and Hepatic Glycogen Metabolism Blood glucose levels are meticulously maintained within a functional range through interactions between several organ systems to ensure that metabolic demands are met without adverse toxic effects

A liver stiffness of 25 kPa or higher can rule in clinically significant portal hypertension as a surrogate for HVPG of 10 mmHg or higher, with a 90% positive predictive value, sparing many patients an invasive pressure measurement

Gain would be covered as validation of the plus-size narrative

It is important to identify the patients who might see the most improvement