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Questions remain concerning the drugs long-term effects on the body, in particular the GI tract

In terms of lowering HbA1c, dulaglutide, when administered once a week, was demonstrated to be more effective than exenatide twice a day, by 1.51% vs.0.99% [94]

demonstrated that BBR reduced bilirubin binding to serum proteins in adult rats, likely due to in vivo displacement or inhibition of bilirubin metabolism [160]

A further limitation is that much of the current evidence is derived from poorly designed trials

In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)