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Due to its significant weight loss effects, tirzepatide has also shown potential in managing conditions like non-alcoholic fatty liver disease (NAFLD), though further research is necessary (43)(46)

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GLP-1 receptor activation stimulates calcitonin secretion and C-cell proliferation in rats and mice, leading to thyroid C-cell hyperplasia and, with chronic high-dose exposure, medullary thyroid carcinoma (MTC)