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Adding 2.0mL works but means drawing larger volumes for each dose
This means that the largest quantities of GLP1 within the CNS are found in the hypothalamus and in the spinal cord, and not in the brainstem where it is produced (Holt, Richards, et al., 2019
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Combines GLP-1-mediated appetite suppression with glucagon-mediated energy expenditure and hepatic lipid metabolism
In cultured human islets and in C57BL/6 mice, both aGLP1 and aGLP1-E2 enhanced glucose-stimulated insulin secretion (GSIS) compared to vehicle and iGLP1-E2 without superior efficacy of aGLP1-E2 compared to GLP-1 alone
