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In this subgroup, 27% of participants randomized to semaglutide de-escalated therapy versus 3% for placebo, and 36% no longer met RHTN criteria at study completion versus 21% in the placebo group

Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial

[42] [43] Liraglutide was approved by the FDA in 2019, for treatment of children aged ten years of age or older with type 2 diabetes, making it the first non-insulin drug approved to treat type 2 diabetes in children since metformin was approved in 2000

By improving metabolic regulation, moderating nutrient signaling, and reducing chronic inflammatory burden, these therapies may help alleviate physiological stress that contributes to age-related disease and functional decline

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