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Conclusion and Discussion This study presents a systematic and computationally-driven framework for the design of semaglutide analogues, emphasizing structural and electrostatic optimization to enhance GLP-1R activation

The patient experienced full remission of BAD symptoms when treated with liraglutide, but only temporary effect of semaglutide, which only improved BAD symptoms during the 2 postinjection days but had no effect during the following 5 days until the next dose (16)

Meal timing: Spread protein across four to six meals
