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In the STEP-1 trial published in The New England Journal of Medicine in 2021, once-weekly subcutaneous semaglutide at 2.4 mg produced a mean placebo-adjusted body weight reduction of 12.4% at 68 weeks in adults with overweight or obesity (Wilding et al., NEJM, 2021)

Some people may also find that certain side effects like headaches or stomach discomfort are more noticeable at night and stop them sleeping

Also, try not to eat too close to bedtime that way, you wont lie down soon after eating