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The GIP receptor (glucose-dependent insulinotropic polypeptide) adds an insulin-sensitizing effect and appears to dampen some of the nausea that pure GLP-1 activation produces

doi: 10.1093/ibd/izae276
[DOI] [PubMed] [Google Scholar] Qian F, Ni N, Burton LS, Wang YF, Desikan S, Hussain M, Smith RL
What are the key industrial constraints in GLP-1 production

People who take metformin can lose, on average, anywhere from five to 15 pounds
