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Key areas of active laboratory investigation utilizing the 16mg formulation include: Triple-Receptor Co-Activation Dynamics: Evaluating the competitive binding kinetics and downstream intracellular signaling cascades triggered when GIP, GLP-1, and glucagon receptors are saturated concurrently

Question 3: Do you want the strongest currently-available mechanism a GIP/GLP-1 dual-agonist without waiting for the triple-agonist pipeline

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However, it remains an open question how both activation and inhibition of GIPR can lead to beneficial effects, and whether the presence of the E354Q variant at the GIPR may affect the efficacy of GLP-1R agonists (GLP-1RAs)