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GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion

Your clinician may consider alternative diabetes or weight management strategies if headaches prove intractable despite optimisation efforts

As The New Yorker has observed, the rise of GLP-1s marks a shift not only in medicine but in cultureas appetite-modulating drugs move from treating diabetes toward shaping body ideals, identity, and social aspiration

The findings, published in the journal Diabetes, Obesity and Metabolism, provide real-world context to previous randomized clinical trials indicating that patients who stopped semaglutide (sold under the brand names Ozempic/Wegovy) and tirzepatide (sold under the brand names Mounjaro/Zepbound) regained more than half of the weight they lost within 12 months

In addition to its metabolic effects, GLP-1 acts centrally to maintain energy balance by activating glucagon-like peptide-1 receptors (GLP-1Rs) located in key regions of the brain