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Description
The chimeric GLP-1-(His 7 -Leu 20 )/glucagon-(Asp 21 -Thr 35 ) is unable to bind and activate GCGR, but its binding affinity and potency are rescued by substituting the 7TMD of GCGR with the 7TMD of GLP-1R, suggesting that the N-terminal region of GLP-1 (His 7 -Leu 20 ) interacts with the 7TMD of GLP-1R (Runge et al., 2003b)

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Prior attempts to manage diabetes through diet or exercise

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