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doi: 10.1016/J.MOLMET.2019.09.010

Sylvester spoke with Bloomberg Law about FDAs proposed changes to the GRAS (Generally Recognized as Safe) pathway, noting the proposals rapid development, the statutory authority questions it presents, and its potential implications for the food and beverage industry: To view or add a comment, sign in Kentucky may allow THC beverages to be sold in bars and restaurants

Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist T2DM: Type-2 diabetes mellitus DPP-4: Dipeptidyl peptidase 4 HbA1c: Hemoglobin A1c NASH: Non-alcoholic steatohepatitis NAFLD: Non-alcoholic fatty liver disease Camp: Cyclic adenosine monophosphate PKA: Protein kinase A EPAC: Exchange protein directly activated by cAMP PI3K: Phosphoinositide 3-kinase PYY: Peptide YY CCK: Cholecystokinin GLUT4: Glucose transporter type 4 mTORC1: Mammalian target of rapamycin complex 1 References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes

"We need more data on the long-term effects and other outcomes related to cardiovascular health, particularly in lower-risk individuals," says Eva Madrid, co-lead researcher from the Universidad de Valparaso, Chile