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The GI side effects that make some people miserable on higher doses are minimal or absent at lower doses

However, past pancreatitis is not a contraindication for these agents, and contrary to the previous warning, recent studies have not shown an increased pancreatic risk associated with GLP-1 RAs, leading to ongoing revisions in treatment guidelines
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Mineralocorticoid receptor antagonists with sodium-glucose co-transporter-2 inhibitors in heart failure: a meta-analysis

Rossing, D
