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El ncleo arcuato del hipotlamo est cercano a la eminencia media, un rgano circunventricular que posee una barrera hemato-enceflica defectuosa (rica en capilares fenestrados), por ende puede identificar nutrientes y hormonas contenidas en la circulacin y enviar estas seales al ncleo arcuato

En el subgrupo de 1130 pacientes con alto riesgo renal (TFGe 33.9 mg/dl], reduccin sostenida de la TFGe 30% o necesidad de terapia de reemplazo renal) fue 15 % menor en la rama dulaglutida (HR: 0.85

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Tan Y., Zhen Q., Ding X., Shen T., Liu F., Wang Y., Zhang Q., Lin R., Chen L., Peng Y., et al

The Medicines and Healthcare products Regulatory Agency (MHRA) and manufacturers' Summaries of Product Characteristics (SmPCs) consistently advise against using GLP-1 receptor agonists whilst breastfeeding due to insufficient data on excretion into human breast milk and potential effects on nursing infants
