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Clinical Diabetes, 41(2), 226238

Given these limitations, complementary approaches such as chimeric antigen receptor T cell (CAR-T) therapy have shown promising potential to overcome PD-1/PD-L1-driven immunosuppression

Theyre actually designed to stay in the blood, which is good for diabetes but bad for Alzheimers because a drug that stays in the blood doesnt get into the brain. At Kariya, Hlscher has designed drugs to be taken up into the brain that he said show much better effects in preclinical studies

Zealand and Boehringer Ingelheim have survodutide in Phase 3 trials and is included in the GLP-1 Pipeline Update

Microdosing may offer an unofficial solution to stretch the supply of these drugs further, allowing patients to continue their treatments while waiting for new shipments to arrive